I can't resist bringing up the alien scene from Woody Allen's Stardust Memories, since I saw it recently, but this dialogue between the main character & super-intelligent Martians stuck strongly with me:
SANDY BATES: "Wait, don't go, I have some questions!"
MARTIAN: "We can't breathe your air!"
"Yeah, at the rate we're going, we're not gonna be able to either. You guys gotta tell me, why is there so much human suffering?"
"This is unanswerable!"
"Is there a God?"
"These are the wrong questions!"
"Look, here's my point. If nothing lasts, why am I bothering to - to make films, or do anything, for that matter?"
"We enjoy your films. Particularly the early, funny ones."
"But the human condition is so discouraging. Shouldn't I stop making movies and do something that counts, like - like helping blind people, or becoming a missionary or something?"
"Let me tell you, you're not the missionary type. You'd never last. And - and incidentally, you're also not Superman. You're a comedian. You wanna do mankind a real service? Tell funnier jokes."
If everybody did what they were best at, at their best, life would be much easier.